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Changes in total phospholipids, phosphatidylethanolamine (PE) and phosphatidylcholine (PC) in liver were studied in relation to various types of abnormal liver function. The fractional ratios of PE/PC in liver tissue in various types of chronic liver diseases were markedly reduced, as compared with the corresponding ratios in normal liver tissue. The level of PE/PC in liver tissue was significantly decreased, irrespective of the type of abnormal liver function, and the reduced amount was not normalized by resection of the involved liver. The reduced amount of PE/PC in liver tissue was closely related to the degree of impairment of liver function. In some cases of persistent elevated serum ALT, the level of PE/PC in liver tissue was still decreased. While the level of PE/PC in liver tissue was raised in some cases of persistent elevated serum GOT. After resection of the involved liver, the fractional ratio of PE/PC in liver tissue was normalized within 1 week, irrespective of the type of abnormal liver function. The treatment with steroid hormones was found to augment the reduced level of PE/PC in liver tissue. The early decrease of fractional ratio of PE/PC in liver tissue in cases of chronic hepatitis may be explained by the utilization of PC as an energy source for maintenance of normal function of hepatocyte. The present findings suggest that it might be important for prevention and/or treatment of chronic liver diseases, to keep the lipid metabolism in liver cells at a healthy state.
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import numpy as np
def _one_hot_arrays(categorical, num_labels):
if isinstance(categorical, list):
num_categories = len(categorical)
else:
num_categories = np.int64(categorical)
one_hot_labels = []
for i in range(num_categories):
one_hot_labels.append(num_labels * np.ones((num_labels, 1)))
one_hot_labels[-1] *= -1.0
return np.array(one_hot_labels)
def _assert_all_finite(x):
x = np.copy(x)
for i, v in enumerate(x):
if not np.isfinite(v):
raise ValueError(“Element %d of x was infinite” % i)
def _get_updates(updates, grads, var_list=None, mask=None,
colocate_gradients_with_ops=True, strict=True):
if isinstance
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